Pearl Street Brewery

La Crosse, Wisconsin · Driftless & Southwest

Pearl Street Brewery is a beloved microbrewery and taproom in La Crosse, Wisconsin, anchoring the city's storied craft-beer identity along the banks of the Mississippi River. Founded in 1999, the brewery operates out of a historic former rubber-mill building that lends the space a rugged, industrial character perfectly suited to its unpretentious, community-first spirit. Flagship beers like El Hefe Rye and Dankenstein IPA have earned loyal followings across the region, showcasing the brewery's range from sessionable wheat ales to bold, hop-forward pints. The sprawling taproom regularly fills with live music and Friday-night energy, making it as much a cultural gathering place as a destination for well-crafted beer. Sitting at the westernmost edge of the Driftless & Southwest region, Pearl Street draws both locals and travelers passing through one of Wisconsin's most historically rich river cities, and after more than two decades it remains the undisputed heart of La Crosse's brewing scene.

Address: 1401 Saint Andrew St, La Crosse, WI 54603

Official website: https://pearlstreetbrewery.com